Publication

PUBLICATIONS

・ Hsiao YT, Yoshida Y, Okuda S, Abe M, Mizuno S, Takahashi S, Nakagami H, Morishita R, Kamimura K, Terai S, Aung TM, Li J, Furihata T, Tang JY, Walsh K, Ishigami A, Minamino T, Shimizu I. PCPE-1, a brown adipose tissue-derived cytokine, promotes obesity-induced liver fibrosis. EMBO Journal. 2024 Aug 19. doi: 10.1038/s44318-024-00196-0.

・ Katsuumi G*, Shimizu I*, Suda M, Yoshida Y, Furihata T, Joki Y, Hsiao CL, Jiaqi L, Fujiki S, Abe M, Sugimoto M, Soga T & Minamino T. SGLT2 inhibition eliminates senescent cells and alleviates pathological aging. Nature Aging. 2024 May 30, *Co-first author.

・ Shimizu I, Exploration of new therapies for heart failure targeting age-related mechanisms. Circ J 2023.

・ Shimizu I. “Reproducibility and Reporting of Negative Results in Cardiovascular Research” from the perspective of mid-career investigator. J Mol Cell Cardiol Plus. (in press)

・Furuuchi R*, Shimizu I*,**, Yoshida Y, Katsuumi G, Suda M, Kubota Y, Walsh K, Minamino T. Endothelial SIRT-1 has critical role for the maintenance of capillarization in brown adipose tissue. iScience. 2022 Nov18, 25, 105424. *Co-first author, **Co-corresponding author

・Yoshida Y*, Shimizu I*,**, Shimada A, Nakahara K, Yanagisawa S, Kubo M, Fukuda S, Ishii C,

Yamamoto H, Ishikawa T, Kano K, Aoki J, Hayashi Y, Ikegami R, Katsuumi G, Suda M, Ozaki K, Kashimura T, Izumi D, Yoshida Y, Okuda S, Ohta S, Okamoto S, Minokoshi Y, Oda K, Sasaoka T, Abe M, Sakimura K, Kubota Y, Yoshimura N, Kajimura S, Zuriaga M, Walsh K, Soga T** and Minamino T**. Brown adipose tissue dysfunction promotes heart failure via a trimethylamine N-oxide-dependent mechanism. Sci Rep. 2022 Sep 1;12(1):14883. *Co-first author, **Co-corresponding author

・Hayashi Y*, Shimizu I*,**, Yoshida Y*, Ikegami R, Suda M, Katsuumi G, Nakao M, Fujiki S, Abe M, Sakimura K, Okuda S, Hayano T, Walsh K, Jespersen NJ, Nielsen S, Scheele C, Minamino T**. Coagulation factors promote brown adipose tissue dysfunction and abnormal systemic metabolism in obesity. iScience. 2022 Jun 7;25(7):104547. *Co-first author, **Co-corresponding

・Suda M*, Shimizu I*, Katsuumi G, Yoshida Y, Matsumoto N, Yoshida Y, Katayama A, Wada J, Seki M, Suzuki Y, Okuda S, Ozaki K, Matsui M, Minamino T. Glycoprotein nonmetastatic melanoma protein B regulates lysosomal integrity and lifespan of senescent cells. Sci Rep. 2022, April 20, 6522. *Co-first author.

・Yoshida Y*, Shimizu I*,**, Minamino T*. Capillaries as a therapeutic target for heart failure. J Atheroscler Thromb. 1;29(7):971-988. April1, 2022. *Joint senior authors, **Corresponding

・Yoshida Y*, Shimizu I*, Yung Ting Hsiao*, Hayashi Y, Suda M, Katsuumi G, Ikegami R, Nakao M, Sakai R, Seki M, Suzuki Y, Okuda S, Soga T, Minamino T. Differing impact of phosphoglycerate mutase 1-deficiency on brown and white adipose tissue. iScience. 2022 Apr 18;25(5):104268 *Co-first author

・Park N, Marquez J, Pham T, Ko TH, Youm JB, Kim M, Choi SH, Moon J, Flores J, Ko K, Rhee BD, Shimizu I, Minamino T, Ha JD, Hwang JY, Yang SJ, Park CS, Kim HK and Han J. Cereblon contributes to cardiac dysfunction by degrading Cav1.2α. European Heart Journal. 2022, Feb; 22.

・Hsiao Y T*, Shimizu I*,**, Yoshida Y, Minamino T**. Role of circulating molecules in age-related cardiovascular and metabolic disorders. Inflammation and regeneration. 42(1):2, Jan1, 2022. *Co-first author, **Co-corresponding author

・Nakao M, Shimizu I*,**, Katsuumi G, Yoshida Y, Suda M, Hayashi Y, Ikegami R, Hsiao Yung Ting, Okuda S, Soga T, Minamino T**. Empagliflozin Maintains Capillarization and Improves Cardiac Function in a Murine Model of Left Ventricular Pressure Overload. Sci Rep. 11, Article number: 18384 (2021). *Co-first author, **Co-corresponding

・Cho K, Ushiki T, Ishiguro H Tamura S, Araki M, Suwabe T, Katagiri T, Ohashi R, Ajioka Y, Shimizu I, Okuda S, Masuko M, Nakagawa Y, Hirai H, Alexander W, Shimano H, Sone H. Altered Microbiota by a High-Fat Diet Accelerates Lethal Myeloid Hematopoiesis Associated with Systemic Socs3 Deficiency. iScience. (in press).

・Suda M*, Shimizu I*, Katsuumi G, Yoshida Y, Matsumoto N, Hayashi Y, Ikegami R Yoshida Y, Mikawa R, Katayama A, Wada J, Seki M, Suzuki Y, Iwama A, Nakagami H, Nagasawa A, Morishita R, Sugimoto M, Okuda S, Tsuchida M, Ozaki K, Matsui M, Minamino T. Senolytic vaccination improves pathological aging. Nature aging. *Co-first author

・Hsiao YT*, Shimizu I*,**, Wakasugi T, Jiao S, Watanabe T, Yoshida Y, Ikegami R, Hayashi Y, Suda M, Katsuumi G, Nakao M, Ozawa T, Kashimura T, Ozaki K, Hanawa H, Minamino T**. Cardiac Mitofusin-1 is Reduced in Non-responding Patients with Idiopathic Dilated Cardiomyopathy. Sci Rep. Mar24; 11(1):6722, 2021.*Co-first author, **Co-corresponding author

・Kim HK, Ko T, Song I, Jeong Y, Heo HJ, Jeong S, Kim M, Park NM, Seo DY, Kha PT, Kim SW, Lee SR, Cho SW, Won JC, Youm JB, Ko K, Rhee B, Kim N, Cho KI, Shimizu I, Minamino T, Ha NC, Park Y, Nilius B, Han J. BH4 activates CaMKK2 and rescues the cardiomyopathic phenotype in rodent models of diabetes. Life Science Alliance. 2020 Jul 22;3(9):e201900619.

・Shimizu I*, Minamino T*. Cellular senescence in arterial diseases. Journal of lipid and atherosclerosis. 9(1):79-91, 2020. *Co-corresponding author

・Fujiki S, Iijima K, Okabe M, Niwano S, Tsujita K, Naito S, Ando K, Kusano K, Kato R, Nitta J, Miura T, Mitsuhashi T, Kario K, Kondo Y, Ieda M, Hagiwara N, Murohara T, Takahashi K, Tomita H, Takeishi Y, Anzai T, Simizu W, Watanabe M, Morino Y, Kato T, Tada H, Nakagawa Y, Yano M, Maemura K, Kimura T, Yoshida H, Ota K, Tanaka T, Node K, Aizawa Y, Shimizu I, Izumi D, Ozaki K, and Minamino T. On behalf of the EMPA-ICD investigators. Placebo-controlled, double-blind study of empagliflozin (EMPA) and implantable cardioverter-defibrillator (EMPA-ICD) in patients with type 2 diabetes (T2DM): rationale and design. Diabetes Ther. 2020 Nov;11(11):2739-2755.

・Fujiki S, Watanabe H, Obata H, Suda M, Mitsuma W, Tomii A, Sakai K, Uehara A, Shimizu I, Kashimura T, Ozaki K, Minamino M. Association of adipokines with frailty in heart failure. Acta Biomed. 2021 Jul 1;92(3):e2021195.

・Kim HK, Jeon J, Song IS, Heo HJ, Jeong SH, Long LT, Thu VT, Ko TH, Kim M, Kim N, Lee SR, Yang JS, Kang MS, Ahn JM, Cho JY, Ko KS, Rhee BD, Nilius B, Ha NC, Shimizu I, Minamino T, Cho KI, Park YS, Kim S, Han J. Tetrahydrobiopterin enhances mitochondrial biogenesis and cardiac contractility via stimulation of PGC1α signaling. Biochim Biophys Acta Mol Basis Dis. 2019 Aug2; S0925-4439(19)30241-8

・Shimizu I*, Minamino T. Cellular senescence in cardiac diseases. J Cardiol. 2019 Jun 12; S0914-5087(19)30128-5 *Co-corresponding author

・Yoshida Y*, Shimizu I*, Hayashi Y, Ikegami R, Suda M, Katsuumi G, Wakasugi T, Nakao M, Nakagmi H, Morishita R, Minamino T. Peptide vaccine for semaphorin3E ameliorates systemic glucose intolerance in mice with dietary obesity. Sci Rep. 2019 Mar7; 9(1)3858 *Co-first author

・Yokoyama M*, Shimizu I*, Nagasawa A, Yoshida Y, Katsuumi G, Wakasugi T, Hayashi Y, Ikegami R, Suda M, Ota Y, Okada S, Fruttiger M, Kobayashi Y, Tsuchida M, Kubota Y, Minamino T. p53 plays a crucial role in endothelial dysfunction associated with hyperglycemia and ischemia. J Mol Cell Cardiol. 129:105-117, 2019. *Co-first author

・Wakasugi T*, Shimizu I*, Yoshida Y, Hayashi Y, Ikegami R, Suda M, Katsuumi G, Nakao M, Hoyano M Kashimura T, Nakamura K, Ito H, Nojiri T, Soga T, Minamino T. Role of smooth muscle cell p53 in pulmonary arterial hypertension. PLOS One. (IF 3.24) (CI8), 14(2)e0212889, 2019. *Co-first author

・Ikegami R*, Shimizu I*,**, Sato T*, Yoshida Y, Hayashi Y, Suda M, Katsuumi G, Li J, Wakasugi T, Minokoshi Y, Okamoto S, Hinoi E, Nielsen S, Jespersen N, Scheele C, Soga T, Minamino T**. Gamma-aminobutyric acid signaling in brown adipose tissue promotes systemic metabolic dysfunction in obesity. *Co-first author, **Co-corresponding author Cell Rep. 24(11):2827-28372018

・Furuuchi R*, Shimizu I*, Yoshida Y, Hayashi Y, Ikegami R, Suda M, Katsuumi G, Wakasugi T, Nakao M, Minamino T. Boysenberry polyphenol inhibits endothelial dysfunction and improves vascular health. PLOS One. 13(8):e0202051, 2018. *Co-first author

・Kayamori H, Shimizu I, Yoshida Y, Hayashi Y, Suda M, Ikegami R, Katsuumi G, Wakasugi T, Minamino T. Amlodipine inhibits vascular cell senescence and protects against atherogenesis through the mechanism independent of calcium channel blockade. Int Heart J. 2018 May 30;59(3):607-613

・Katsuumi G*, Shimizu I*, Yoshida Y, Minamino T. Vascular senescence in cardiovascular and metabolic diseases. Front Cardiovasc Med. 05 March 2018 https://doi.org/10.3389/fcvm.2018.00018. *Co-first author

・Ikegami R*, Shimizu I*, Yoshida Y, Minamino T. Metabolomic analysis in heart failure. Circ J. 2017 ;82(1):10-16 *Co-first author

・Katsuumi G*, Shimizu I*,**, Yoshida Y, Minamino T**. Inflammation and regeneration. 2016 Aug 36;16. The pathological role of vascular aging in cardio-metabolic disorder. *Co-first author, **Co-corresponding author

・Suda M*, Shimizu I*, Yoshida Y, Minamino T. Peripheral blood mononuclear cells for limb ischemia. Therapeutic Angiogenesis. (Springer publication). p25-43, 2017, *Co-first author

・Yoshida Y*, Shimizu I*,**, Minamino T**. Diabetes and adipocyte dysfunction. Diabetes and Aging-related Complications, 69-84 (Springer publication). *Co-first author, **Co-corresponding author

・Suda M*, Shimizu I*, Yoshida Y, Hayashi Y, Ikegami R, Katsuumi G, Wakasugi T, Yoshida Y, Okuda S, Soga T, Minamino T. Inhibition of Dipeptidyl peptidase-4 ameliorates cardiac ischemia and systolic dysfunction by up-regulating the FGF-2/EGR-1 pathway. *Co-first author PLOS One. 2017 Aug 3; 12(8), e0182422.

・Kinoshita D, Nagasawa A, Shimizu I, Ito T, Yoshida Y, Tsuchida M, Iwama A, Hayano T and Tohru Minamino. Progerin impairs vascular smooth muscle cell growth via the DNA damage response pathway. Oncotarget. 2017 May 23;8(21):34045-34056

・Shimizu I*, Minamino T*. Physiological and pathological cardiac hypertrophy. J Mol Cell Cardiol. 2016 Jun 2;97:245-262*Co-corresponding author

・Maruyama S, Nakamura K, Papanicolaou N.K., Shimizu I, Sano S, Asaumi Y, van den Hoff M.J., Ouchi N, Recchia A.F., Walsh K. EMBO Mol Med. 2016 Aug 1; 8(8):949-66. Follistatin-like 1 is an endogenous regulator of cardiac fibroblast activation that protects the heart from post-infarct rupture.

・Shimizu I, Yoshida Y, Minamino T. Hypertens Res. 2016 Feb 18, A role for circadian clock in metabolic disease.

・Nakamura K, Sano S, Fuster J, Kikuchi R, Shimizu I, Ohshima K, Katanasaka Y, Ouchi N, and Walsh K. J Biol Chem. 2015 Feb 5;291(6):2566-75 Sfrp5 diminishes cardiac inflammation and protects the heart from ischemia-reperfusion injury.

・Shimizu I, Yoshida Y, Minamino T. Diabetes. 2015 (Commentary) Dec;64(12):3984-6. Maintenance of subcutaneous fat homeostasis improves systemic metabolic dysfunction in obesity.

・Nakagomi A, Okada S, Yokoyama M, Yoshida Y, Shimizu I, Miki T, Kobayashi Y, and Minamino T. Aging and Mechanism of Disease. (Nature publishing group) 2015 October, Role of the central nervous system and adipose tissue BDNF/TrkB axes in metabolic regulation.

・Yoshida Y*, Shimizu I*, Minamino T. Inflammation and regeneration. 2015 September, The pathological role of adipose tissue aging in the progression of systemic insulin resistance. *Co-first author

・Yoshida Y*, Shimizu I*, Katsuumi G*, Suda M, Hayashi Y, Minamino T. J Mol Cell Cardiol. 2015 June 85:183-198. p53-induced inflammation exacerbates cardiac dysfunction during pressure overload. *Co-first author

・Shimizu I*, Yoshida Y, Minamino T*. Int Heart J. 2015 May 13;56(3):255-9. Pathological role of adipose tissue dysfunction in cardio-metabolic disorders. *Co-corresponding author

・Shimizu I*, Walsh K. Curr Obes Rep. 2015 June 4;(2):224-229. Whitening of brown fat and implications for weight management in obesity. *Corresponding author

・Shimizu I, Yoshida Y, Suda M, Minamino T. Cell Metab. 2014 Dec 2;20(6):967-977. DNA damage response and metabolic disease.

・Suzuki H, Kayama Y, Sakamoto M, Iuchi H, Shimizu I, Yoshino T, Katoh D, Nagoshi T , Tojo K, Minamino T, Yoshimura M, Utsunomiya K. Diabetes. 2015 Feb;64(2):618-30. Arachidonate 12/15-lipoxygenase-induced inflammation and oxidative stress are involved in the development of Diabetic Cardiomyopathy

・Kikuchi R, Nakamura K, Maclauchlan S, Ngo D, Shimizu I, Fuster J, Katanasaka Y, Yoshida S, Qiu Y, Yamaguchi T, Matsushita T, Murohara T, Gokce N, Bates D, Hamburg N, Walsh K. Nat Med. 2014 Dec;20(12):1464-71. An anti-angiogenic isoform of VEGF-A contributes to impaired vascularization in peripheral artery disease.

・Yoshida Y, Hayashi Y, Suda M, Tateno K, Okada S, Moriya J, Yokoyama M, Nojima A, Yamashita M, Kobayashi Y, Shimizu I, Minamino T. PLOS One. 2014 Jun 20;9(6). Notch Signaling Regulates the Lifespan of Vascular Endothelial Cells via a p16-Dependent Pathway.

・Yokoyama M, Okada S, Nakagomi A, Moriya J, Shimizu I, Nojima A, Yoshida Y, Ichimiya H, Kamimura N, Kobayashi Y, Ohta S, Fruttiger M, Lozano G, Minamino T. Cell Rep. 2014 Jun12;7(5):1691-703. Inhibition of endothelial p53 improves metabolic abnormalities related to dietary obesity.

・Shimizu I, Tamar A, Kikuchi R, Shimizu A, Papanicolaou K, Maclauchlan S, Maruyama S, Walsh K. J Clin Invest. 2014; May;124(5):2099-112. Vascular rarefaction mediates whitening of brown fat in obesity.

・Shimizu I, Yoshida Y, Moriya J, Nojima A, Uemura A, Kobayashi Y, Minamino T. Cell Metab. 2013 Oct1;18(4):491-504.Semaphorin3E-induced inflammation contributes to insulin resistance in dietary obesity. (Featured article)

・Nojima A, Yamashita M, Yoshida Y, Shimizu I, Ichimiya H, Kamimura N, Kobayashi Y, Ohta S, Ishii Naoaki, Minamino T. PLOS One. 2013 Jul; 30;8(7). Haploinsufficiency of Akt1 prolongs the lifespan of mice.

・Shimizu I, Walsh K. J Mol Cell Cardiol. 2013 Jun;59:176-8. Vascular remodeling mediated by Angptl2 produced from perivascular adipose tissue.

・Shimizu I, Yoshida Y, Katsuno T, Minamino T. Microbes and Infection. 2013; 1:11-7. Adipose tissue inflammation in diabetes and heart failure.

・Tomita K, Teratani T, Suzuki T, Oshikawa T, Yokoyama H, Shimamura K, Nishiyama K, Mataki N, Irie R, Minamino T, Okada Y, Kurihara C, Ebinuma H, Saito H, Shimizu I, Yoshida Y, Hokari R, Sugiyama K, Hatsuse K, Yamamoto J, Kanai T, Miura S, Hibi T. J Hepatol. 2012; 57, 837-843. P53/p66Shc-mediated signaling contributes to the progression of non-alcoholic steatohepatitis in humans and mice.

・Naito AT, Sumida T, Nomura S, Liu ML, Higo T, Nakagawa A, Okada K, Sakai T, Hashimoto A, Hara Y, Shimizu I, Zhu W, Toko H, Katada A, Akazawa H, Oka T, Lee JK, Minamino T, Nagai T, Walsh K, Kikuchi A, Matsumoto M, Botto M, Shiojima I, Komuro I. Cell. 2012; 149: 1298-313. Complement C1q Activates Canonical Wnt Signaling and Promotes Aging-Related Phenotypes.

・Okada S, Yokoyama M, Toko H, Tateno K, Moriya J, Shimizu I, Nojima A, Ito T, Yoshida Y, Kobayashi Y, Katagiri H, Minamino T, Komuro I. Arterioscler Thromb Vasc Biol. 2012; 8: 1902-9. Brain-derived neurotrophic factor protects against cardiac dysfunction after myocardial infarction via a central nervous system-mediated pathway.

・Shimizu I, Yoshida Y, Katsuno T, Tateno K, Okada S, Moriya J, Yokoyama M, Nojima A, Ito T, Zechner R, Komuro I, Kobayashi Y, Minamino T. Cell Metab. 2012; 15:51-64. p53-induced adipose tissue inflammation is critically involved in the development of insulin resistance in heart failure. (Featured article)

・Yasuda N, Akazawa H, Ito K, Shimizu I, Kudo-Sakamoto Y, Yabumoto C, Yano M, Yamamoto R, Ozasa Y, Minamino T, Naito AT, Oka T, Shiojima I, Tamura K, Umemura S, Nemer M, Komuro I. Hypertension. 2012; 59: 627-33. Agonist-independent constitutive activity of angiotensin II receptor promotes cardiac remodeling in mice.

・Shimizu I, Minamino T, Toko H, Okada S, Ikeda H, Yasuda N, Tateno K, Moriya J, Yokoyama M, Nojima A, Koh G, Akazawa H, Shiojima I, Kahn C, Abel E, & Komuro I. J Clin Invest. 2010;120:1506-1514. Excessive cardiac insulin signaling exacerbates systolic dysfunction induced by pressure overload in rodents.

・Moriya J, Minamino T, Tateno K, Okada S, Akiyoshi U. Shimizu I, Yokoyama M, Nojima A, Henderson CE, Okada M, Koga H, Komuro I. Circ Res. 2010; 106:391-8. Inhibition of Semaphorin As a Novel Strategy for Therapeutic Angiogenesis.

・Minamino T*, Orimo M*, Shimizu I*, Kunieda T, Yokoyama M, Ito T, Nojima A, Nabetani A, Oike Y, Matsubara H, Ishikawa F, Komuro I. Nat Med. 2009; 15:1082-7. A crucial role for adipose tissue p53 in the regulation of insulin resistance. *Co-first author

・Kayama Y, Minamino T, Toko H, Sakamoto M, Shimizu I, Takahashi H, Okada S, Tateno K, Moriya J, Yokoyama M, Nojima A, Yoshimura M, Egashira K, Aburatani H and Komuro I. J. Exp. Med. 2009; 206:1565-74. Cardiac 12/15-lipoxygenase-induced inflammation is involved in heart failure.

・Shimizu I, Iguchi N, Watanabe H, Umemura J, Tobaru T, Asano R, Misu K, Nagayama M, Aikawa M Funabashi N, Komuro I, Sumiyoshi T. Int J Cardiol. 2010; 142:224-9. Delayed enhancement cardiovascular magnetic resonance as a novel technique to predict cardiac events in dilated cardiomyopathy patients.

・Sano M, Minamino T, Toko H, Miyauchi H, Orimo M, Qin Y, Akazawa H, Tateno K, Kayama Y, Harada M, Shimizu I, Asahara T, Hamada H, Tomita S, Molkentin JD, Zou Y, Komuro I. Nature. 2007; 446:444-8. p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload.